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Article

Pattern of usage of the VH4-21 gene by B lymphocytes in a patient with EBV infection indicates ongoing mutation and class switching.

Molecular immunology - 1 Apr 1995

Chapman C J, Spellerberg M B, Hamblin T J, Stevenson F K

Abstract excerpt

Following infection with EBV, patients have selectively raised serum levels of immunoglobulins encoded by the VH4-21 gene. In order to follow the detailed pattern of usage of the VH4-21 gene by blood B lymphocytes of a typical patient during infection, EBV lines were established, and transformed B cells were hybridized and cloned. In addition, to widen the genetic analysis, cDNA preparations from the EBV...

Topics

Adult
Amino Acid Sequence
B-Lymphocytes
Base Sequence
Clone Cells
Female
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Humans
Hybridomas
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infectious Mononucleosis

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Source

Identifiers

PMID: 7739572
DOI: 10.1016/0161-5890(94)00162-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7739572-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Pattern of usage of the VH4-21 gene by B lymphocytes in a patient with EBV infection indicates ongoing mutation and class switching.PMID 7739572Read ↗

Pattern of usage of the VH4-21 gene by B lymphocytes in a patient with EBV infection indicates ongoing mutation and class switching.Semantic proximity Read ↗

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Autoanti-red cell antibodies synthesized by patients with infectious mononucleosis utilize the VH4-21 gene segment.Semantic proximity Read ↗

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Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity.Semantic proximity Read ↗

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Human anti-Gal heavy chain genes. Preferential use of VH3 and the presence of somatic mutations.Semantic proximity Read ↗

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Use of IGHV3–21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post–germinal center leukemogenic selectionSemantic proximity Read ↗

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