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Article

[Correlation of immunoglobulin variable heavy chain gene mutation status with prognosis in patients with mantle cell lymphoma].

Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 Feb 2015

Ji Hong, Tang Yuan, He Yanmei, Jiang Wei, Liao Dianying, Liu Weiping, Li Gandi

Abstract excerpt

OBJECTIVE: To study the relationship between immunoglobulin variable heavy chain (IgVH) gene mutation status and clinical features, pathologic findings and biologic behavior of mantle cell lymphoma (MCL). METHODS: IgVH gene was amplified in 60 cases of MCL with FR1-JH and FR2-JH primers in BIOMED-2. The sequence was determined by cloning. The IgVH somatic mutational status was analyzed using NCBI's Ig-Blast tool....

Topics

DNA Primers
Female
Genes, Immunoglobulin Heavy Chain
Humans
Immunoglobulin Variable Region
Lymphoma, Mantle-Cell
Male
Mutation
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25916638

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