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Somatic hypermutation and V<sub>H</sub> gene usage in mantle cell lymphoma

1 Apr 2002

Abstract excerpt

Mantle cell lymphoma (MCL) is considered to derive from naïve, pregerminal center (GC) CD5+ B-cells. However, the cell of origin has been questioned in recent studies that showed somatic hypermutations in the immunoglobulin (Ig) variable heavy chain (V(H)) genes in subsets of MCL. To clarify this issue, we analyzed the IgV(H) genes for the presence of somatic hypermutations in 51 MCL cases. Twenty percent of the...

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PMID: 12071937
DOI: 10.1034/j.1600-0609.2002.01662.x

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