Article
Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations.
Blood - 15 May 2003
Camacho Francisca I, Algara Patrocinio, Rodríguez Antonia, Ruíz-Ballesteros Elena, Mollejo Manuela, Martínez Nerea, Martínez-Climent José A, González Marcos, Mateo Marisol, Caleo Alessia, Sánchez-Beato Margarita, Menárguez J, García-Conde Javier, Solé Francesc, Campo Elias, Piris Miguel A
Abstract excerpt
This study explores whether the presence of somatic mutations or a biased use of IgV(H) genes were associated with the clinical features in a series of 96 patients with mantle cell lymphoma (MCL). The cases were studied by seminested polymerase chain reaction using primers from the FR1 and J(H) regions. There was an unexpectedly high frequency of somatic mutations, with 29 of 103 sequences showing more than 2% of...
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