Immunoglobulin heavy chain genes somatic hypermutations and chromosome 11q22-23 deletion in classic mantle cell lymphoma: a study of the Swiss Group for Clinical Cancer Research.

doi:10.1046/j.1365-2141.2003.04763.x

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Article

Immunoglobulin heavy chain genes somatic hypermutations and chromosome 11q22-23 deletion in classic mantle cell lymphoma: a study of the Swiss Group for Clinical Cancer Research.

British journal of haematology - 1 Feb 2004

Bertoni Francesco, Conconi Annarita, Cogliatti Sergio B, Schmitz Shu-Fang Hsu, Ghielmini Michele, Cerny Thomas, Fey Martin, Pichert Gabriella, Bertolini Francesco, Ponzoni Maurilio, Baldini Luca, Jones Chris, Auer Rebecca, Zucca Emanuele, Cavalli Franco, Cotter Finbarr E

Abstract excerpt

Mantle cell lymphoma (MCL) shares immunophenotypic and karyotypic features with chronic lymphocytic leukaemia. The latter comprises two distinct entities with prognosis dependent upon immunoglobulin heavy chain (IgH) gene mutational status and the presence of 11q deletion. We evaluated the relevance of IgH gene mutational status, IgV gene family usage and presence of 11q deletion in a series of 42 histologically...

Topics

Aged
Chromosomes, Human, Pair 11
Female
Gene Deletion
Genes, Immunoglobulin
Humans
Lymphoma, Mantle-Cell
Male
Middle Aged

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PMID: 14717775
DOI: 10.1046/j.1365-2141.2003.04763.x

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