Article
Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.
Nature cell biology - 1 Apr 2003
Yamanaka Koji, Ishikawa Haruto, Megumi Yuzuru, Tokunaga Fuminori, Kanie Masato, Rouault Tracey A, Morishima Isao, Minato Nagahiro, Ishimori Koichiro, Iwai Kazuhiro
Abstract excerpt
The ubiquitin system is involved in several basic cellular functions. Ubiquitination is carried out by a cascade of three reactions catalysed by the E1, E2 and E3 enzymes. Among these, the E3 ubiquitin-protein ligases have a pivotal role in determining the specificity of the system by recognizing the target substrates through defined targeting motifs. Although RING finger proteins constitute an important family...
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