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Article

The E2 ubiquitin-conjugating enzyme HIP2 is a crucial regulator of quality control against mutant SOD1 proteotoxicity.

Biochimica et biophysica acta. Molecular basis of disease - 1 Feb 2022

Tak Yeong Jin, Kang Seongman

Abstract excerpt

Mutations in superoxide dismutase 1 (SOD1) leading to the formation of intracellular protein aggregates cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder characterized by a selective degeneration of motor neurons. The ALS-linked mutant SOD1 emerged as a possible target for ubiquitin-proteasome system (UPS)-mediated degradation. We aimed to elucidate the role of huntingtin interaction...

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PMID: 34856358
DOI: 10.1016/j.bbadis.2021.166316

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