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LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance

2025-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Adaptation to fluctuating nutrient supply is essential for organismal survival, but how cells sense and respond to changes in the abundance of many critical nutrients remains undefined. One such example is the amino acid cysteine, whose reactive thiol group is exploited for diverse cellular functions. Here, by characterizing the machinery required for the conditional degradation of cysteine diox...

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Identifiers and source

Literature Corpus work
ef72641b-e43f-562b-abb3-8593fd9fb709
DOI
10.1101/2025.09.23.678073
Open publication

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LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundanceDOI 10.1101/2025.09.23.678073
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