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Article

Mdm2 is a target and mediator of IRP2 in cell growth control

12 Dec 2019

Abstract excerpt

Iron is an essential element to all living organisms and plays a vital role in many cellular processes, such as DNA synthesis and energy production. The Mdm2 oncogene is an E3 ligase and known to promote tumor growth. However, the role of Mdm2 in iron homeostasis is not certain. Here, we showed that Mdm2 expression was increased by iron depletion but decreased by iron repletion. We also showed that Iron...

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PMID: 31907996
DOI: 10.1096/fj.201902278rr

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