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Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis

9 Oct 2024

Abstract excerpt

Ferroptosis is an iron-dependent, non-apoptotic form of cell death initiated by oxidative stress and lipid peroxidation. Recent evidence has linked ferroptosis to the action of the transcription factor Nuclear factor erythroid-2 derived,-like-1 (NFE2L1). NFE2L1 regulates proteasome abundance in an adaptive fashion, maintaining protein quality control to secure cellular homeostasis, but the regulation of NFE2L1...

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PMID: 39384955
DOI: 10.1038/s41418-024-01398-z

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