Article
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis
2023-07-04
Abstract excerpt
Ferroptosis is an iron-dependent, non-apoptotic form of cell death initiated by oxidative stress and lipid peroxidation. Recent evidence has linked ferroptosis to the action of the transcription factor Nuclear factor erythroid-2 derived,-like-1 (NFE2L1). NFE2L1 regulates proteasome abundance in an adaptive fashion, maintaining protein quality control to secure cellular homeostasis, but the regulation of NFE2L1 dur...
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Identifiers and source
- Literature Corpus work
- 17817216-979a-5e5f-b8a3-0cbe0ca45e3a
- DOI
- 10.1101/2023.07.04.547652