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The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family

11 Jan 2023

Abstract excerpt

The RING-between-RING (RBR) E3 ubiquitin ligase family in humans comprises 14 members and is defined by a two-step catalytic mechanism in which ubiquitin is first transferred from an E2 ubiquitin-conjugating enzyme to the RBR active site and then to the substrate. To define the core features of this catalytic mechanism, we here structurally and biochemically characterise the two RBRs HOIL-1 and RNF216. Crystal...

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PMID: 36631489
DOI: 10.1038/s41467-023-35871-z

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