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Article

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity.

Molecular and cellular biology - 1 Feb 2004

Wang Jian, Chen Guohua, Muckenthaler Martina, Galy Bruno, Hentze Matthias W, Pantopoulos Kostas

Abstract excerpt

Iron regulatory protein 2 (IRP2), a central posttranscriptional regulator of cellular and systemic iron metabolism, undergoes proteasomal degradation in iron-replete cells. The prevailing model postulates that the mechanism involves site-specific oxidation of 3 cysteine residues (C168, C174, and...

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Identifiers

PMID: 14729944
DOI: 10.1128/MCB.24.3.954-965.2004
PMCID: PMC321427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14729944-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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