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Article

The Ubiquitin Ligase Siah2 and the Hypoxia Response

1 Apr 2009

Abstract excerpt

Growing evidence indicates that ubiquitin ligases play a critical role in the hypoxia response. Among them, Siah2, a RING finger ligase, is an important regulator of pathways activated under hypoxia. Siah2 regulates prolyl hydroxylases PHD3 and 1 under oxygen concentration of 2% to 5%, thereby allowing accumulation of hypoxia-inducible factor (HIF)-1alpha, a master regulator of the hypoxia response within the...

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Autophagy in Disease and Therapy
Cancer, Hypoxia, and Metabolism
Ubiquitin and proteasome pathways

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19372575
DOI: 10.1158/1541-7786.mcr-08-0458

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