Article
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis
2023-07-19
Abstract excerpt
<title>Abstract</title> <p>Ferroptosis is an iron-dependent, non-apoptotic form of cell death initiated by oxidative stress and lipid peroxidation. Recent evidence has linked ferroptosis to the action of the transcription factor Nuclear factor erythroid-2 derived,-like-1 (NFE2L1). NFE2L1 regulates proteasome abundance in an adaptive fashion, maintaining protein quality control to secure cellular homeostasis, but...
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Identifiers and source
- Literature Corpus work
- d4e97b28-a748-542f-b872-29df5f7cf73b
- DOI
- 10.21203/rs.3.rs-3143510/v1