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Article

Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A.

Mechanisms of development - 1 Apr 2006

Lorente Mar, Pérez Claudia, Sánchez Carmen, Donohoe Mary, Shi Yang, Vidal Miguel

Abstract excerpt

Polycomb group (PcG) proteins participate in the maintenance of transcriptionally repressed state of genes relevant to cell differentiation. Here, we show anterior homeotic transformations of the axial skeleton of YY1(+/-) mice. We find that the penetrance of some of these alterations was reduced in mice that are deficient in the class II PcG gene Ring1/Ring1A, indicating a genetic interaction between those two...

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Anterior Eye Segment
Bone Development
Genes, Homeobox
Musculoskeletal Abnormalities
Polycomb-Group Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polycomb Repressive Complex 1

YY1 Transcription Factor

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PMID: 16624538
DOI: 10.1016/j.mod.2006.02.003

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Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A.PMID 16624538Read ↗

YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment.Semantic proximity Read ↗

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YY1 DNA binding and PcG recruitment requires CtBP.Semantic proximity Read ↗

Yin Yang 1 physically interacts with Hoxa11 and represses Hoxa11-dependent transcription.Semantic proximity Read ↗

Juxtaposed Polycomb complexes co-regulate vertebral identity.Semantic proximity Read ↗

Transcription factor YY1 functions as a PcG protein in vivo.Semantic proximity Read ↗

The polycomb group protein ring1b/rnf2 is specifically required for craniofacial development.Semantic proximity Read ↗

Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition.Semantic proximity Read ↗

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The Drosophila Polycomb group gene Sex combs extra encodes the ortholog of mammalian Ring1 proteins.Semantic proximity Read ↗

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