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Article

Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2003

Silverman Karen A, Koratkar Revati A, Siracusa Linda D, Buchberg Arthur M

Abstract excerpt

We recently identified the Modifier of Min 2 (Mom2) locus. Mom2 is a new modifier of intestinal tumorigenesis that resulted from a spontaneous mutation in a B6 Apc(Min)/+ mouse. The presence of one resistant Mom2(R) allele results in a significant reduction in small intestinal polyp number and colon polyp incidence in Apc(Min)/+ mice. Through linkage analysis, we previously localized Mom2 to a 14-cM region on...

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PMID: 12584607
DOI: 10.1007/s00335-002-2214-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus.PMID 12584607Read ↗

Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.Semantic proximity Read ↗

The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression.Semantic proximity Read ↗

Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice.Semantic proximity Read ↗

Genetic dissection of the Mom5 modifier locus and evaluation of Mom5 candidate genes.Semantic proximity Read ↗

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.Semantic proximity Read ↗

Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse.Semantic proximity Read ↗

Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis.Semantic proximity Read ↗

ROSA26 mice carry a modifier of Min-induced mammary and intestinal tumor development.Semantic proximity Read ↗

Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to ApcMin intestinal tumorigenesis.Semantic proximity Read ↗

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis.Semantic proximity Read ↗

Identification of novel modifier loci of Apc Min affecting mammary tumor development.Semantic proximity Read ↗

Absence of frequent involvement of modifier of Min(APC) in sporadic colorectal cancer.Semantic proximity Read ↗

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