Article
Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.
Genetics - 1 Jun 2007
Kwong Lawrence N, Shedlovsky Alexandra, Biehl Bryan S, Clipson Linda, Pasch Cheri A, Dove William F
Abstract excerpt
The Apc(Min) mouse model of colorectal cancer provides a discrete, quantitative measurement of tumor multiplicity, allowing for robust quantitative trait locus analysis. This advantage has previously been used to uncover polymorphic modifiers of the Min phenotype: Mom1, which is partly explained by Pla2g2a; Mom2, a spontaneous mutant modifier; and Mom3, which was discovered in an outbred cross. Here, we describe...
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