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Article

Identification of novel modifier loci of Apc Min affecting mammary tumor development.

Cancer research - 1 Dec 2007

Wang Hua, Teske Douglas, Tess Alyssa, Kohlhepp Rebecca, Choi YounJeong, Kendziorski Christina, Moser Amy Rapaich

Abstract excerpt

Genetic background affects the susceptibility to mammary tumor development in Apc(Min/+) mice. Here we report the identification of four novel modifier loci that influence different aspects of mammary tumor development in Apc(Min/+) mice. Analysis of tumor development in a backcross of (FVBB6 Apc(Min/+)) x B6 Apc(Min/+) mice has identified a modifier on chromosome 9 that significantly affects tumor multiplicity,...

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Source

Identifiers

PMID: 18056448
DOI: 10.1158/0008-5472.CAN-07-2487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of novel modifier loci of Apc Min affecting mammary tumor development.PMID 18056448Read ↗

Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.Semantic proximity Read ↗

ROSA26 mice carry a modifier of Min-induced mammary and intestinal tumor development.Semantic proximity Read ↗

Somatic mutational mechanisms involved in intestinal tumor formation in Min mice.Semantic proximity Read ↗

Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis.Semantic proximity Read ↗

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.Semantic proximity Read ↗

Multistep carcinogenesis of the colon in Apc(Min/+) mouse.Semantic proximity Read ↗

A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice.Semantic proximity Read ↗

Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice.Semantic proximity Read ↗

Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice.Semantic proximity Read ↗

The ROSA26 LacZ-neo(R) insertion confers resistance to mammary tumors in Apc(Min/+) mice.Semantic proximity Read ↗

The CAST/Ei strain confers significant protection against Apc(Min) intestinal polyps, independent of the resistant modifier of Min 1 (Mom1) locus.Semantic proximity Read ↗

ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.Semantic proximity Read ↗

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