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Article

Genetic dissection of the Mom5 modifier locus and evaluation of Mom5 candidate genes.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2015

Otterpohl Karla L, Gould Karen A

Abstract excerpt

Germline mutations in the adenomatous polyposis coli (APC) gene cause familial adenomatous polyposis (FAP), a hereditary colon cancer syndrome in which affected individuals may develop 100-1000s of colonic adenomas. In families affected by FAP, adenoma number can vary markedly between individuals, despite the fact that these individuals carry the same APC mutation. In at least some FAP pedigrees, evidence...

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Share to Adenomatous Polyposis Coli
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25976411
DOI: 10.1007/s00335-015-9567-x

Genes

FAP
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic dissection of the Mom5 modifier locus and evaluation of Mom5 candidate genes.PMID 25976411Read ↗

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