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Article

Absence of frequent involvement of modifier of Min(APC) in sporadic colorectal cancer.

Annals of surgical oncology - 1 Mar 1998

Kahlenberg M S, Stoler D L, Petrelli N J, Rodriguez-Bigas M, Weber T K, Anderson G R

Abstract excerpt

BACKGROUND: Mutations in the multiple intestinal neoplasia (Min) gene, the mouse homologue of the APC gene, result in the development of intestinal tumors. The degree of tumor expression is suppressed by the modifier of Min (MOM). Alterations in the MOM gene result in markedly increased tumor expression in the mouse. The human homologue of the MOM gene has been mapped to a locus on chromosome 1p35-36, but the...

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Source

Identifiers

PMID: 9527272
DOI: 10.1007/BF02303852

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absence of frequent involvement of modifier of Min(APC) in sporadic colorectal cancer.PMID 9527272Read ↗

Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis.Semantic proximity Read ↗

Emergent issues in the genetics of intestinal neoplasia.Semantic proximity Read ↗

A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice.Semantic proximity Read ↗

Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.Semantic proximity Read ↗

Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms.Semantic proximity Read ↗

The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression.Semantic proximity Read ↗

Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus.Semantic proximity Read ↗

Intestinal adenomas can develop with a stable karyotype and stable microsatellitesSemantic proximity Read ↗

Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse.Semantic proximity Read ↗

Loss of heterozygosity in spontaneous and x-ray-induced intestinal tumors arising in F1 hybridMin mice: Evidence for sequential loss ofApc+ andDpc4 in tumor developmentSemantic proximity Read ↗

Somatic genetic events linked to the Apc locus in intestinal adenomas of the Min mouse.Semantic proximity Read ↗

Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice.Semantic proximity Read ↗

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