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Article

Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice.

PloS one - 1 Jan 2009

Elahi Eiram, Suraweera Nirosha, Volikos Emmanouil, Haines Jackie, Brown Natalie, Davidson Gerovie, Churchman Mike, Ilyas Mohammed, Tomlinson Ian, Silver Andrew

Abstract excerpt

Ionising radiation is a carcinogen capable of inducing tumours, including colorectal cancer, in both humans and animals. By backcrossing a recombinant line of Apc(Min/+) mice to the inbred BALB/c mouse strain, which is unusually sensitive to radiation-induced tumour development, we obtained panels of 2Gy-irradiated and sham-irradiated N2 Apc(Min/+) mice for genotyping with a genome-wide panel of microsatellites...

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Identifiers

PMID: 19194513
DOI: 10.1371/journal.pone.0004388
PMCID: PMC2633613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice.PMID 19194513Read ↗

Loss of heterozygosity in spontaneous and x-ray-induced intestinal tumors arising in F1 hybridMin mice: Evidence for sequential loss ofApc+ andDpc4 in tumor developmentSemantic proximity Read ↗

Genetic mapping of novel modifiers for ApcMin induced intestinal polyps’ development using the genetic architecture power of the collaborative cross miceSemantic proximity Read ↗

Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.Semantic proximity Read ↗

The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression.Semantic proximity Read ↗

Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis.Semantic proximity Read ↗

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.Semantic proximity Read ↗

Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus.Semantic proximity Read ↗

Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestineSemantic proximity Read ↗

Direct single gene mutational events account for radiation-induced intestinal adenoma yields in Apc(Min/+) mice.Semantic proximity Read ↗

Degree and site of chromosomal instability define its oncogenic potentialSemantic proximity Read ↗

Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to ApcMin intestinal tumorigenesis.Semantic proximity Read ↗

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis.Semantic proximity Read ↗

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