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Article

The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression.

Genome research - 1 May 2007

Baran Amy A, Silverman Karen A, Zeskand Joseph, Koratkar Revati, Palmer Ashley, McCullen Kristen, Curran Walter J, Edmonston Tina Bocker, Siracusa Linda D, Buchberg Arthur M

Abstract excerpt

Inactivation of the APC gene is considered the initiating event in human colorectal cancer. Modifier genes that influence the penetrance of mutations in tumor-suppressor genes hold great potential for preventing the development of cancer. The mechanism by which modifier genes alter adenoma incidence can be readily studied in mice that inherit mutations in the Apc gene. We identified a new modifier locus of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intestinal Polyposis

Share to Mice, Inbred C57BL

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Share to Mitochondrial Proton-Translocating ATPases

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Source

Open in PubMed Open full text

Identifiers

PMID: 17387143
DOI: 10.1101/gr.6089707
PMCID: PMC1855180

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression.PMID 17387143Read ↗

Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus.Semantic proximity Read ↗

Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.Semantic proximity Read ↗

Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis.Semantic proximity Read ↗

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.Semantic proximity Read ↗

Genetic dissection of the Mom5 modifier locus and evaluation of Mom5 candidate genes.Semantic proximity Read ↗

Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice.Semantic proximity Read ↗

Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice.Semantic proximity Read ↗

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis.Semantic proximity Read ↗

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Identification of novel modifier loci of Apc Min affecting mammary tumor development.Semantic proximity Read ↗

Loss of heterozygosity in spontaneous and x-ray-induced intestinal tumors arising in F1 hybridMin mice: Evidence for sequential loss ofApc+ andDpc4 in tumor developmentSemantic proximity Read ↗

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