Article
The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.
Cell - 16 Jun 1995
MacPhee M, Chepenik K P, Liddell R A, Nelson K K, Siracusa L D, Buchberg A M
Abstract excerpt
Mutations in the APC gene are responsible for various familial and sporadic colorectal cancers. Min mice carry a dominant mutation in the homolog of the Apc gene and develop multiple adenomas throughout their small and large intestine. Quantitative trait loci studies have identified a locus, Mom1...
Topics
- Adenomatous Polyposis Coli
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- Crosses, Genetic
- DNA, Complementary
- Female
- Gene Expression
- Genes, APC
- Genes, Dominant
- Intestinal Neoplasms
- Male
- Mice
- Mice, Inbred AKR
- Mice, Mutant Strains
- Models, Biological