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Article

Temperature-dependent conformational changes in herpes simplex virus ICP4 that affect transcription activation.

Journal of virology - 1 Mar 2003

Compel Peter, DeLuca Neal A

Abstract excerpt

The C-terminal 500 amino acids of herpes simplex virus type 1 ICP4 are required for full activator function and viral growth and are known to participate in interactions consistent with the role of ICP4 as an activator of transcription. Oligonucleotide mutagenesis was used to target stretches of amino acids that are conserved with the ICP4 analogs of other alphaherpesviruses and were also predicted to be exposed...

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Identifiers

PMID: 12584349
DOI: 10.1128/jvi.77.5.3257-3268.2003
PMCID: PMC149779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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