Identification of dominant-negative mutants of the herpes simplex virus type 1 immediate-early protein ICP0.

doi:10.1128/JVI.66.4.2261-2267.1992

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Article

Identification of dominant-negative mutants of the herpes simplex virus type 1 immediate-early protein ICP0.

Journal of virology - 1 Apr 1992

Weber P C, Wigdahl B

Abstract excerpt

ICP0 is a 110,000-molecular-weight immediate-early protein of herpes simplex virus type 1 (HSV-1) which is encoded by three exons. It has been shown to function as a promiscuous transactivator of a variety of different HSV-1 and non-HSV-1 promoters in transient expression assays. Analysis of muta...

Topics

Animals
Exons
Immediate-Early Proteins
Molecular Weight
Mutation
Simplexvirus
Transcriptional Activation
Ubiquitin-Protein Ligases
Vero Cells
Viral Proteins

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