Article
Phosphorylation site mutations affect herpes simplex virus type 1 ICP0 function.
Journal of virology - 1 Jan 2005
Davido David J, von Zagorski William F, Lane William S, Schaffer Priscilla A
Abstract excerpt
The herpes simplex virus type 1 (HSV-1) immediate-early (IE) regulatory protein infected-cell protein 0 (ICP0) is a strong and global transactivator of both viral and cellular genes. In a previous study, we reported that ICP0 is highly phosphorylated and contains at least seven distinct phosphorylation signals as determined by phosphotryptic peptide mapping (D. J. Davido et al., J. Virol. 76:1077-1088, 2002)....
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