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Article

Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression.

Virology - 1 Jan 1992

Smith I L, Hardwicke M A, Sandri-Goldin R M

Abstract excerpt

The herpes simplex virus (HSV-1) immediate early protein ICP27 is a regulatory protein which is essential for virus replication. The phenotype of temperature-sensitive and deletion mutants in ICP27 includes overexpression of some immediate early and early gene products and greatly reduced levels of late gene products. To determine whether regulation by ICP27 occurs primarily at the transcriptional level, we have...

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Identifiers

PMID: 1309283
DOI: 10.1016/0042-6822(92)90062-t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression.PMID 1309283Read ↗

Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins.Semantic proximity Read ↗

The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expressionSemantic proximity Read ↗

The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infectionSemantic proximity Read ↗

Immediate-early expression of the herpes simplex virus type 1 ICP27 transcript is not critical for efficient replication in vitro or in vivo.Semantic proximity Read ↗

Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27.Semantic proximity Read ↗

Herpes simplex virus 1 ICP27 is required for transcription of two viral late (gamma 2) genes in infected cells.Semantic proximity Read ↗

Herpes simplex virus ICP27 increases translation of a subset of viral late mRNAs.Semantic proximity Read ↗

Mutations in the activation region of herpes simplex virus regulatory protein ICP27 can be trans dominant.Semantic proximity Read ↗

Intracellular localization of the herpes simplex virus type 1 major transcriptional regulatory protein, ICP4, is affected by ICP27.Semantic proximity Read ↗

The many roles of the regulatory protein ICP27 during herpes simplex virus infectionSemantic proximity Read ↗

The Many Roles of the Highly Interactive HSV Protein ICP27, A Key Regulator of InfectionSemantic proximity Read ↗

Identification of herpes simplex virus RNAs that interact specifically with regulatory protein ICP27 in vivo.Semantic proximity Read ↗

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