Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression.

doi:10.1016/0042-6822(92)90062-t

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Article

Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression.

Virology - 1 Jan 1992

Smith I L, Hardwicke M A, Sandri-Goldin R M

Abstract excerpt

The herpes simplex virus (HSV-1) immediate early protein ICP27 is a regulatory protein which is essential for virus replication. The phenotype of temperature-sensitive and deletion mutants in ICP27 includes overexpression of some immediate early and early gene products and greatly reduced levels...

Topics

Animals
Blotting, Northern
Gene Expression Regulation, Viral
Genes, Viral
Immediate-Early Proteins
In Vitro Techniques
Mutation
RNA Processing, Post-Transcriptional
RNA, Messenger
RNA, Viral
Simplexvirus
Temperature
Transcription, Genetic
Vero Cells
Viral Envelope Proteins
Viral Proteins
Viral Structural Proteins

Source

Open in PubMed

Identifiers

PMID: 1309283
DOI: 10.1016/0042-6822(92)90062-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1309283-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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