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Article

Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential gene regulation function.

Journal of virology - 1 Feb 1994

Rice S A, Lam V

Abstract excerpt

ICP27 is an essential herpes simplex virus type 1 (HSV-1) alpha protein that is required for the transition from the beta to the gamma phase of infection. To identify functional regions of ICP27, we constructed 16 plasmids that contain nucleotide substitution mutations in the ICP27 gene. The mutations created XhoI restriction sites, altered one or two codons, and were spaced at semiregular intervals throughout...

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Identifiers

PMID: 8289386
DOI: 10.1128/JVI.68.2.823-833.1994
PMCID: PMC236519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential gene regulation function.PMID 8289386Read ↗

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