Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential gene regulation function.

doi:10.1128/JVI.68.2.823-833.1994

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Article

Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential gene regulation function.

Journal of virology - 1 Feb 1994

Rice S A, Lam V

Abstract excerpt

ICP27 is an essential herpes simplex virus type 1 (HSV-1) alpha protein that is required for the transition from the beta to the gamma phase of infection. To identify functional regions of ICP27, we constructed 16 plasmids that contain nucleotide substitution mutations in the ICP27 gene. The muta...

Topics

Amino Acids
Base Sequence
Gene Expression Regulation, Viral
Genes, Lethal
Genes, Regulator
Genes, Viral
Genetic Complementation Test
Herpesvirus 1, Human
Immediate-Early Proteins
Molecular Sequence Data
Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Plasmids

RNA, Messenger

RNA, Viral

Recombinant Proteins

Trans-Activators

Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8289386
DOI: 10.1128/JVI.68.2.823-833.1994
PMCID: PMC236519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8289386-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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