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Article

A second-site revertant of a defective herpes simplex virus ICP4 protein with restored regulatory activities and impaired DNA-binding properties.

Journal of virology - 1 Feb 1991

Shepard A A, DeLuca N A

Abstract excerpt

A mutant of herpes simplex virus type 1, vi12, encodes a DNA-binding- and transactivation-deficient ICP4 polypeptide. Because of the mutation, the vi12 virus does not grow on Vero cells but must be propagated on cells that express complementing levels of wild-type ICP4 (E5 cells). A pseudorevertant of vi12, designated pri12, was isolated on the basis of the restored ability to replicate on Vero cells. In addition...

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Identifiers

PMID: 1846199
DOI: 10.1128/JVI.65.2.787-795.1991
PMCID: PMC239818

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