Repression of the herpes simplex virus 1 alpha 4 gene by its gene product (ICP4) within the context of the viral genome is conditioned by the distance and stereoaxial alignment of the ICP4 DNA binding site relative to the TATA box.

Abstract excerpt

Infected cell protein no. 4 (ICP4), the major regulatory protein encoded by the alpha 4 gene of herpes simplex virus 1, binds to a site (alpha 4-2) at the transcription initiation site of the alpha 4 gene. An earlier report described the construction of recombinant viruses that contained chimeric genes (alpha 4-tk) that consisted of the 5' untranscribed and transcribed noncoding domains of the alpha 4 gene fused...

Topics

• Animals
• Base Sequence
• Binding Sites
• Chlorocebus aethiops
• DNA, Viral
• DNA-Binding Proteins
• Genes, Viral
• Genome, Viral
• Herpesvirus 1, Human
• Immediate-Early Proteins