trans-dominant inhibition of herpes simplex virus transcriptional regulatory protein ICP4 by heterodimer formation.

doi:10.1128/JVI.64.8.3916-3926.1990

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Article

trans-dominant inhibition of herpes simplex virus transcriptional regulatory protein ICP4 by heterodimer formation.

Journal of virology - 1 Aug 1990

Shepard A A, Tolentino P, DeLuca N A

Abstract excerpt

Herpes simplex virus encodes a 175-kilodalton immediate-early transactivating protein referred to as ICP4. A mutant ICP4 molecule expressed from a stable transformed cell line lacks the sequences required for transactivation yet retains the ability to specifically associate with DNA and to form h...

Topics

Animals
Cell Transformation, Viral
Chromatography, Gel
DNA-Binding Proteins
Immediate-Early Proteins
Macromolecular Substances
Methionine
Molecular Weight
Mutation
Plasmids
Protein Conformation
Simplexvirus
Transcription Factors
Vero Cells
Viral Proteins
Viral Regulatory and Accessory Proteins

Source

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Identifiers

PMID: 2164603
DOI: 10.1128/JVI.64.8.3916-3926.1990
PMCID: PMC249687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2164603-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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