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Article

Mutations in the activation region of herpes simplex virus regulatory protein ICP27 can be trans dominant.

Journal of virology - 1 Jul 1991

Smith I L, Sekulovich R E, Hardwicke M A, Sandri-Goldin R M

Abstract excerpt

The herpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is an essential regulatory protein which is required for virus replication. Transfection experiments have demonstrated that ICP27 along with the HSV-1 transactivators ICP4 and ICP0 can positively regulate the expression of some late HSV-1 target plasmids and can negatively regulate the expression of some immediate-early and early target...

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Identifiers

PMID: 1645788
DOI: 10.1128/JVI.65.7.3656-3666.1991
PMCID: PMC241377

Genes

CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in the activation region of herpes simplex virus regulatory protein ICP27 can be trans dominant.PMID 1645788Read ↗

Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential gene regulation function.Semantic proximity Read ↗

Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27.Semantic proximity Read ↗

Intracellular localization of the herpes simplex virus type 1 major transcriptional regulatory protein, ICP4, is affected by ICP27.Semantic proximity Read ↗

The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infectionSemantic proximity Read ↗

Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression.Semantic proximity Read ↗

Identification of dominant-negative mutants of the herpes simplex virus type 1 immediate-early protein ICP0.Semantic proximity Read ↗

Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression.Semantic proximity Read ↗

Immediate-early expression of the herpes simplex virus type 1 ICP27 transcript is not critical for efficient replication in vitro or in vivo.Semantic proximity Read ↗

Identification of herpes simplex virus RNAs that interact specifically with regulatory protein ICP27 in vivo.Semantic proximity Read ↗

Processing of alpha-globin and ICP0 mRNA in cells infected with herpes simplex virus type 1 ICP27 mutants.Semantic proximity Read ↗

Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins.Semantic proximity Read ↗

The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expressionSemantic proximity Read ↗

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