Article
Mutations in the activation region of herpes simplex virus regulatory protein ICP27 can be trans dominant.
Journal of virology - 1 Jul 1991
Smith I L, Sekulovich R E, Hardwicke M A, Sandri-Goldin R M
Abstract excerpt
The herpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is an essential regulatory protein which is required for virus replication. Transfection experiments have demonstrated that ICP27 along with the HSV-1 transactivators ICP4 and ICP0 can positively regulate the expression of some late HSV-1 target plasmids and can negatively regulate the expression of some immediate-early and early target...
Topics
- Amino Acid Sequence
- Base Sequence
- Blotting, Northern
- Cloning, Molecular
- DNA Mutational Analysis
- DNA Replication
- Gene Expression
- Gene Expression Regulation, Viral
- Genes, Dominant
- Immediate-Early Proteins