Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer.

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Article

Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer.

Cancer research - 1 Feb 2003

Tseng Tzu-Ling, Shih Yi-Ping, Huang Yu-Chuen, Wang Chung-Kwe, Chen Pao-Huei, Chang Jan-Gowth, Yeh Kun-Tu, Chen Yi-Ming Arthur, Buetow Kenneth H

Abstract excerpt

Glycine N-methyltransferase (GNMT), a multifunctional protein involved in the maintenance of the genetic stability, is often down-regulated in hepatocellular carcinoma (HCC). Using genotypic characterization of GNMT in hepatoma cell lines and in a Taiwanese population with a high incidence of liver cancer we have investigated the role of this gene in the progression of liver cancer. Six novel polymorphisms,...

Topics

Alleles
Base Sequence
Carcinoma, Hepatocellular
DNA, Neoplasm
Electrophoresis
Genetic Predisposition to Disease
Genotype
Glycine N-Methyltransferase
Humans
Liver Neoplasms
Loss of Heterozygosity
Methyltransferases
Polymorphism, Genetic

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 12566309

Genes

GNMT

Provenance

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