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Article

Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway.

Cancer research - 15 May 2004

Chen Shih-Yin, Lin Jane-Ru Vivan, Darbha Ramalakshmi, Lin Pinpin, Liu Tsung-Yun, Chen Yi-Ming Arthur

Abstract excerpt

Glycine N-methyltransferase (GNMT) affects genetic stability by (a) regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and (b) binding to folate. Based on the identification of GNMT as a 4 S polyaromatic hydrocarbon-binding protein, we used liver cancer cell lines that expressed GNMT either transiently or stably in cDNA transfections to analyze the role of GNMT in the benzo(a)pyrene (BaP)...

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Source

Identifiers

PMID: 15150120
DOI: 10.1158/0008-5472.CAN-03-3726

Genes

GNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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