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Article

Genome-wide analyses on loss of heterozygosity in hepatocellular carcinoma in Southern China.

Journal of hepatology - 1 Jun 2001

Li S P, Wang H Y, Li J Q, Zhang C Q, Feng Q S, Huang P, Yu X J, Huang L X, Liang Q W, Zeng Y X

Abstract excerpt

BACKGROUND/AIMS: To conduct a genome-wide analysis of loss of heterozygosity (LOH) and its clinical significance in hepatocellular carcinoma (HCC) in Southern China where high incidence of HCC was documented. METHODS: LOH of 382 microsatellite loci on all autosomes were detected with polymerase chain reaction-based microsatellite polymorphism analyses in 104 HCC tumor tissues. RESULTS: High frequency of LOH...

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PMID: 11451167
DOI: 10.1016/s0168-8278(01)00047-2

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