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Article

Epigenetic silencing of glutaminase 2 in human liver and colon cancers

1 Dec 2013

Abstract excerpt

BACKGROUND: Glutaminase 2 (Gls2) is a p53 target gene and is known to play an important role in energy metabolism. Gls2 has been reported to be downregulated in human hepatocellular carcinomas (HCC). However, the underlying mechanism responsible for its downregulation is still unclear. Here, we investigated Gls2 expression and its promoter methylation status in human liver and colon cancers. METHODS: mRNA...

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PMID: 24330717
DOI: 10.1186/1471-2407-13-601

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