Article
Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility.
International journal of cancer - 15 Feb 2009
Liao Yi-Jen, Liu Shih-Ping, Lee Cheng-Ming, Yen Chia-Hung, Chuang Pei-Chun, Chen Chia-Yen, Tsai Ting-Fen, Huang Shiu-Feng, Lee Yan-Hwa Wu, Chen Yi-Ming Arthur
Abstract excerpt
Hepatocellular carcinoma (HCC) is the fifth common cancer in the world and it mainly occurs in men. Glycine N-methyltransferase (GNMT) participates in one-carbon metabolism and affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine. Previously, we described that the expression of GNMT was diminished in human HCC. Here, we showed that 50% (3/6) male and 100% (7/7) female...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.