Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility.

doi:10.1002/ijc.23979

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Article

Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility.

International journal of cancer - 15 Feb 2009

Liao Yi-Jen, Liu Shih-Ping, Lee Cheng-Ming, Yen Chia-Hung, Chuang Pei-Chun, Chen Chia-Yen, Tsai Ting-Fen, Huang Shiu-Feng, Lee Yan-Hwa Wu, Chen Yi-Ming Arthur

Abstract excerpt

Hepatocellular carcinoma (HCC) is the fifth common cancer in the world and it mainly occurs in men. Glycine N-methyltransferase (GNMT) participates in one-carbon metabolism and affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine. Previously, we described that the expression of GNMT was diminished in human HCC. Here, we showed that 50% (3/6) male and 100% (7/7) female...

Topics

Animals
Carcinoma, Hepatocellular
DNA Methylation
Family Health
Female
Genetic Predisposition to Disease
Glycine N-Methyltransferase
Humans
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Knockout

Mutation, Missense

Sex Factors

Wnt Proteins

Source

Open in PubMed

Identifiers

PMID: 19035462
DOI: 10.1002/ijc.23979

Genes

GNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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