Article
Using loss of heterozygosity of microsatellites to distinguish high-grade dysplastic nodule from early minute hepatocellular carcinoma.
Experimental and molecular pathology - 1 Oct 2011
Dong Hui, Cong Wen-Ming, Xian Zhi-Hong, Zhu Zhong-Zheng
Abstract excerpt
BACKGROUND: It is practical significant to seek new applicable adjuvant diagnostic biomarkers to differentiate high-grade dysplastic nodule (HGDN) from well-differentiated minute hepatocellular carcinoma (w-MHCC) due to their closely overlapping morphology. METHODS: In the present study, by using microdissection-based paraffin-embedded tissues, loss of heterozygosity (LOH) patterns of a panel of 22 microsatellite...
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