Article
The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression.
Blood - 1 Jun 2003
Joutsi-Korhonen Lotta, Smethurst Peter A, Rankin Angela, Gray Elaine, IJsseldijk Martin, Onley Catherine M, Watkins Nicholas A, Williamson Lorna M, Goodall Alison H, de Groot Philip G, Farndale Richard W, Ouwehand Willem H
Abstract excerpt
Interaction of platelets with collagen under conditions of blood flow is a multi-step process with tethering via glycoprotein IbIXV (GPIbIXV) over von Willebrand factor, adhesion by direct interaction with the integrin GPIaIIa, and signaling via GPVI. GPVI can be specifically agonized by cross-linked collagen-related peptide (CRP-XL), which results in a signaling cascade very similar to that evoked by native...
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