Article
The minor allele of GP6 T13254C is associated with decreased platelet activation and a reduced risk of recurrent cardiovascular events and mortality: results from the SMILE-Platelets project.
Journal of thrombosis and haemostasis : JTH - 1 Nov 2010
Snoep J D, Gaussem P, Eikenboom J C J, Emmerich J, Zwaginga J J, Holmes C E, Vos H L, de Groot Ph G, Herrington D M, Bray P F, Rosendaal F R, van der Bom J G
Abstract excerpt
BACKGROUND: Contradictory results have been published on the effects of T13254C (rs1613662), which distinguishes the two major isoforms of GP6, the gene encoding the platelet receptor glycoprotein VI, on platelet function and the risk of cardiovascular disease. METHODS: We performed a population-based case-control study, the Study of Myocardial Infarctions in Leiden, among 547 male patients with a first...
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