Article
A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.
Blood - 13 Aug 2009
Jones Chris I, Bray Sarah, Garner Stephen F, Stephens Jonathan, de Bono Bernard, Angenent Will G J, Bentley David, Burns Philippa, Coffey Alison, Deloukas Panos, Earthrowl Mark, Farndale Richard W, Hoylaerts Marc F, Koch Kerstin, Rankin Angela, Rice Catherine M, Rogers Jane, Samani Nilesh J, Steward Michael, Walker Adam, Watkins Nicholas A, Akkerman Jan-Willem, Dudbridge Frank, Goodall Alison H, Ouwehand Willem H
Abstract excerpt
Platelet response to activation varies widely between individuals but shows interindividual consistency and strong heritability. The genetic basis of this variation has not been properly explored. We therefore systematically measured the effect on function of sequence variation in 97 candidate genes in the collagen and adenosine-diphosphate (ADP) signaling pathways. Resequencing of the genes in 48 European DNA...
Topics
- 3' Untranslated Regions
- Adenosine Diphosphate
- Alleles
- Blood Platelets
- Cell Degranulation
- Collagen
- Europe
- Female
- Gene Expression Regulation