Article
Platelet GP IIIa Pl(A) polymorphisms display different sensitivities to agonists.
Circulation - 7 Mar 2000
Michelson A D, Furman M I, Goldschmidt-Clermont P, Mascelli M A, Hendrix C, Coleman L, Hamlington J, Barnard M R, Kickler T, Christie D J, Kundu S, Bray P F
Abstract excerpt
BACKGROUND: Both inherited predisposition and platelet hyperreactivity have been associated with ischemic coronary events, but mechanisms that support genetic differences among platelets from different subjects are generally lacking. Associations between the platelet Pl(A2) polymorphism of GP IIIa and coronary syndromes raise the question as to whether this inherited variation may contribute to platelet...
Topics
- Abciximab
- Adenosine Diphosphate
- Adult
- Amino Acid Substitution
- Antibodies, Monoclonal
- Aspirin
- Blood Platelets
- Cell Membrane
- Dose-Response Relationship, Drug
- Female
- Fibrinogen