GPVI levels in platelets: relationship to platelet function at high shear.

doi:10.1182/blood-2003-01-0231

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Article

GPVI levels in platelets: relationship to platelet function at high shear.

Blood - 15 Oct 2003

Best Denise, Senis Yotis A, Jarvis Gavin E, Eagleton Helen J, Roberts David J, Saito Takashi, Jung Stephanie M, Moroi Masaaki, Harrison Paul, Green Fiona R, Watson Steve P

Abstract excerpt

We have investigated the density of the collagen receptors glycoprotein VI (GPVI) and alpha 2 beta 1 on human platelets and their relationship to polymorphisms within the GPVI gene. GPVI levels varied 1.5-fold and showed a weak correlation (r = 0.35) with the levels of alpha 2 beta 1, which varied 3-fold. GPVI genotype had a significant effect on receptor levels with carriers of the proline 219 allele...

Topics

Alleles
Animals
Blood Platelets
Cell Adhesion
Collagen
Crotalid Venoms
Flow Cytometry
Genetic Variation
Genotype
Glycoproteins
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Integrin alpha2beta1

Lectins, C-Type

Mice

Mice, Inbred C57BL

Myeloproliferative Disorders

Platelet Membrane Glycoproteins

Source

Open in PubMed

Identifiers

PMID: 12829582
DOI: 10.1182/blood-2003-01-0231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12829582-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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