The influence of platelet glycoprotein polymorphisms on receptor function and risk for thrombosis.

doi:10.1111/j.1423-0410.2002.tb05274.x

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Article

The influence of platelet glycoprotein polymorphisms on receptor function and risk for thrombosis.

Vox sanguinis - 1 Aug 2002

Kunicki Thomas J, Nugent Diane J

Abstract excerpt

With regard to hemostasis and thrombosis, collagens are among the most important physiologic components of the extracellular matrix in their role as platelet activators. Differences in the rate of platelet activation markedly influence normal hemostasis and the pathological outcome of thrombosis. Thus, collagen receptors, such as the integrin alpha2beta1 and indirectly, GPIb alpha, represent a relatively...

Topics

Genetic Predisposition to Disease
Humans
Platelet Membrane Glycoproteins
Polymorphism, Single Nucleotide
Structure-Activity Relationship
Thrombosis

Source

Open in PubMed

Identifiers

PMID: 12617110
DOI: 10.1111/j.1423-0410.2002.tb05274.x

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