Increased platelet-collagen interaction associated with double homozygosity for receptor polymorphisms of platelet GPIa and GPIIIa.

doi:10.1161/01.atv.0000042230.26207.d2

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Article

Increased platelet-collagen interaction associated with double homozygosity for receptor polymorphisms of platelet GPIa and GPIIIa.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2002

Pontiggia Luca, Lassila Riitta, Pederiva Stephanie, Schmid Hans-Rudolf, Burger Mirjam, Beer Juerg H

Abstract excerpt

OBJECTIVE: There is considerable controversy regarding the clinical role of the single-nucleotide polymorphisms (SNPs) of the platelet glycoprotein receptor GPIa C807T and the Pl(A1/A2) of GPIIIa as cardiovascular risk factors. We hypothesized that two combined SNPs in their homozygous prothrombotic forms could clarify their pathophysiological impact. METHODS AND RESULTS: We identified a family with a striking...

Topics

Adult
Blood Platelet Disorders
Blood Platelets
Collagen
Female
Flow Cytometry
Genotype
Homozygote
Humans
Integrin alpha2
Integrin beta3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Microscopy, Electron, Scanning

Middle Aged

Myocardial Infarction

Polymorphism, Single Nucleotide

Prevalence

Source

Open in PubMed

Identifiers

PMID: 12482840
DOI: 10.1161/01.atv.0000042230.26207.d2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12482840-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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