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Article

Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations.

Blood - 27 Aug 2009

Dumont Bénédicte, Lasne Dominique, Rothschild Chantal, Bouabdelli Maxime, Ollivier Véronique, Oudin Claire, Ajzenberg Nadine, Grandchamp Bernard, Jandrot-Perrus Martine

Abstract excerpt

The glycoprotein VI (GPVI)/FcRgamma complex is a key receptor for platelet activation by collagen. We describe, for the first time, 2 genetic abnormalities in one patient. This 10-year-old girl presented ecchymoses since infancy, a prolonged bleeding time despite a normal platelet count and no antiplatelet antibodies. Collagen-induced platelet activation was null, whereas GPVI quantification by flow cytometry...

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Identifiers

PMID: 19549989
DOI: 10.1182/blood-2009-03-213504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations.PMID 19549989Read ↗

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