Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course.

American journal of human genetics - 1 Mar 2003

Barcellos L F, Oksenberg J R, Begovich A B, Martin E R, Schmidt S, Vittinghoff E, Goodin D S, Pelletier D, Lincoln R R, Bucher P, Swerdlin A, Pericak-Vance M A, Haines J L, Hauser S L

Abstract excerpt

Models of disease susceptibility in multiple sclerosis (MS) often assume a dominant action for the HLA-DRB1*1501 allele and its associated haplotype (DRB1*1501-DQB1*0602 or DR2). A robust and phenotypically well-characterized MS data set was used to explore this model in more detail. A dose effect of HLA-DR2 haplotypes on MS susceptibility was revealed. This observation suggests that, in addition to the role of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Progression
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Haplotypes

Share to HLA-DR Antigens

Share to HLA-DR2 Antigen

Share to HLA-DRB1 Chains

Share to Multiple Sclerosis

Share to Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 12557126
DOI: 10.1086/367781
PMCID: PMC1180245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course.PMID 12557126Read ↗

Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis.Semantic proximity Read ↗

The HLA locus and multiple sclerosis in Spain. Role in disease susceptibility, clinical course and response to interferon-beta.Semantic proximity Read ↗

Does the DRB1*1501 allele confer more severe and faster progression in primary progressive multiple sclerosis patients? HLA in primary progressive multiple sclerosis.Semantic proximity Read ↗

HLA (A-B-C and -DRB1) alleles and brain MRI changes in multiple sclerosis: a longitudinal study.Semantic proximity Read ↗

No evidence for an effect of DNA methylation on multiple sclerosis severity at HLA-DRB1*15 or HLA-DRB5.Semantic proximity Read ↗

Multiple sclerosis: doubling down on MHCSemantic proximity Read ↗

The HLA paradox across populations in multiple sclerosis progression: a systematic review.Semantic proximity Read ↗

HLA-DRB1 associations with disease susceptibility and clinical course in Australians with multiple sclerosis.Semantic proximity Read ↗

Genetic basis for clinical expression in multiple sclerosis.Semantic proximity Read ↗

Influence of HLA-DRB1 allele heterogeneity on disease risk and clinical course in a West Australian MS cohort: a high-resolution genotyping study.Semantic proximity Read ↗

HLA-DRB1*1501 influences long-term disability progression and tissue damage on MRI in relapse-onset multiple sclerosis.Semantic proximity Read ↗

HLA genotypes and disease severity assessed by magnetic resonance imaging findings in patients with multiple sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.