Article
HLA genotypes and disease severity assessed by magnetic resonance imaging findings in patients with multiple sclerosis.
Journal of neurology - 1 Sept 2003
Zivadinov Robert, Uxa Laura, Zacchi Tullio, Nasuelli Davide, Ukmar Maja, Furlan Christina, Pozzi-Mucelli Roberto, Tommasi Maria Antonietta, Locatelli Laura, Ulivi Sheila, Bratina Alessio, Bosco Antonio, Grop Attillio, Cazzato Giuseppe, Zorzon Marino
Abstract excerpt
The objective of the study was to examine the relationship between HLA genotypes and disease severity as measured by brain MRI quantitative markers of demyelinating and destructive pathology in patients with multiple sclerosis (MS). We studied 100 patients with MS and 122 age, sex-, ethnic- and residence-matched controls. The DNA extraction and the genomic typing (A, B, DRB1 and DQB1 loci) were obtained with...
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