Article
Influence of HLA-DRB1 allele heterogeneity on disease risk and clinical course in a West Australian MS cohort: a high-resolution genotyping study.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 May 2010
Wu Jing-Shan, James Ian, Wei Qiu, Castley Alison, Christiansen Frank T, Carroll William M, Mastaglia Frank L, Kermode Allan G
Abstract excerpt
BACKGROUND: Previous studies on the influence of HLA-DRB1 alleles on multiple sclerosis (MS) susceptibility and clinical course have mostly employed the 2-point genotyping method. OBJECTIVE: To assess the influence of HLA-DRB1 alleles and allele interactions on disease risk and clinical course in a large West Australian MS patient cohort using high-resolution genotyping. METHODS: Four digit HLA-DRB1 genotyping...
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